The spleen is a common site for metastasis from which cancer?

The spleen is a common site for metastasis from which cancer?

• A. Melanoma
• B. Prostate cancer
• C. Thyroid cancer
• D. Pancreatic cancer

Answer: (A)

Melanoma is known for widespread hematogenous spread and can seed distant sites such as the spleen. Among the cancers listed, it has the strongest association with splenic metastasis, even though splenic involvement is overall less common than metastasis to other organs. Prostate cancer tends to metastasize to bone, thyroid cancers to lymph nodes and lungs, and pancreatic cancer to the liver and peritoneum, making them less likely to involve the spleen as a common metastasis site. In imaging, splenic metastases from melanoma may appear as focal nodules or splenomegaly, reflecting hematogenous seeding by melanoma cells.

Melanoma is known for widespread hematogenous spread and can seed distant sites such as the spleen. Among the cancers listed, it has the strongest association with splenic metastasis, even though splenic involvement is overall less common than metastasis to other organs. Prostate cancer tends to metastasize to bone, thyroid cancers to lymph nodes and lungs, and pancreatic cancer to the liver and peritoneum, making them less likely to involve the spleen as a common metastasis site. In imaging, splenic metastases from melanoma may appear as focal nodules or splenomegaly, reflecting hematogenous seeding by melanoma cells.